| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-436 | |
| Phytochemical name or plant extracts | Isoneorautenol | |
| PMID | 24252341 | |
| Literature evidence | Flow cytometry was used for cell cycle analysis and detection of apoptotic cells, analysis of mitochondrial membrane potential (MMP) as well as measurement of reactive oxygen species (ROS). | |
| IUPAC name | 7,7-dimethyl-8,12,20-trioxapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-2(11),3,5,9,14(19),15,17-heptaen-17-ol | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Erythrina excelsa | |
| Geographical availability | Benin, Burundi, Cameroon, Central African Repu, Congo, Equatorial Guinea, Ivory Coast, Kenya, Liberia, Mali, Nigeria, Sudan, Tanzania, Uganda, Zambia, Zaïre | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Leukemia, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Isoneorautenol induced apoptosis in CCRF-CEM cells via the activation of inititator caspases 8 and 9 and effector caspase 3/7 as well as the loss of MMP and increase in ROS production. | |
| IC50 | 15.85 ± 3.82 μM against MDA-MB-231-pcDNA 2.67 ± 0.16 μM against MDA-MB-231-BCRP | |
| Potency | Compounds 3 showed significant cytotoxicity toward sensitive and drug-resistant cancer cell lines. Compound 3 is Isoneorautenol | |
| Cell line/ mice model | MDA-MB-231, CCRF-CEM, HCT116, U87MG | |
| Additional information | NA | |
| PubChem ID | 73649 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:494420-1 | |
| Safety | NA |