| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1351 | |
| Phytochemical name or plant extracts | Isoflavones extracted from chickpea sprouts (ICS) | |
| PMID | 25287332 | |
| Literature evidence | Isoflavones extracted from chickpea Cicer arietinum L. sprouts induce mitochondria-dependent apoptosis in human breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Cicer arietinum | |
| Geographical availability | Iran, Iraq, Turkey | |
| Plant parts | Seeds, sprouts | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Caspase 7, Caspase 9, p53, P21 | |
| Gene or Protein evidence | We found that ICS induced an increase in the mRNA expression of Bax, as well as a decrease in the mRNA expression of Bcl-2, in both MCF-7 and SKBr3 cell lines, Western blot analysis showed that treatment of SKBr3 and MCF-7 cells with ICS increased the expression of caspase 7, caspase 9, P53, and P21 in a dose-dependent manner. | |
| Target pathways | Activation of caspase 9 triggers a cascade of downstream signals, including caspase 3 and caspase 7, members of the intrinsic mitochondria-dependent apoptotic pathway | |
| IC50 | 41.6 µg/mL against SKBR-3 32.8 µg/mL against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | SKBR-3, MCF-7 | |
| Additional information | ICS also induced an increase in the expression of two tumor suppressor proteins, P53 and P21, which play a vital role in oxidative stress responses | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:486336-1 | |
| Safety | NA |