| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1371 | |
| Phytochemical name or plant extracts | Isocryptotanshinone | |
| PMID | 26155286 | |
| Literature evidence | Hoechst 33342 staining and Western blot analysis for apoptotic proteins suggested that ICTS induced apoptosis in MCF-7 cells. | |
| IUPAC name | 4,4,8-trimethyl-2,3,8,9-tetrahydro-1H-naphtho[2,1-f][1]benzofuran-7,11-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Salvia miltiorrhiza | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer | |
| Target gene or protein | JNK, ERK, p38 MAPK | |
| Gene or Protein evidence | ICTS activated MAPK signaling in MCF-7 cells by inducing time- and concentration-dependent phosphorylation of JNK, ERK, and p38 MAPK. | |
| Target pathways | MAPK signaling pathways | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HepG2, A459 | |
| Additional information | Furthermore, exposure of MCF-7 cells to ICTS induced cell cycle arrest at the G1 phase and decreased mitochondrial membrane potential. | |
| PubChem ID | 626608 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456707-1 | |
| Safety | NA |