| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-750 | |
| Phytochemical name or plant extracts | Isochamanetin | |
| PMID | 31362371 | |
| Literature evidence | Our findings demonstrate the potential applicability of C. kirkii as a source of antimalarial and anticancer agents. | |
| IUPAC name | (2S)-5,7-dihydroxy-6-[(2-hydroxyphenyl)methyl]-2-phenyl-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Cleistochlamys kirkii | |
| Geographical availability | Malawi, Mozambique, Tanzania, Zambia, Zimbabwe | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 11.6 µM against MDA-MB-231 | |
| Potency | This indicates the potential applicability of C. kirkii as a source of antimalarial, and even more likely of anticancer agents. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Heptenolide 13 isolated from the stem ethanolic extract along with flavonoids 2–4, 7 and heptenolide 12 also exhibited potent antiplasmodial activity. The current result suggests that isochamanetin serves as potent binding agent to the cyclinD1. | |
| PubChem ID | 5318528 | |
| Additional PMIDs | 30663403 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:72604-1 | |
| Safety | NA |