| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-55 | |
| Phytochemical name or plant extracts | Isoazadironolide | |
| PMID | 24443427 | |
| Literature evidence | In addition, evaluation of their cytotoxic activities against HL60, A549, AZ521, and SK-BR-3 human cancer cell lines, isoazadironolide (1), 4'-O-methyl-8-prenylnaringenin (5), euchrestaflavanone A (8), 9, and 3-methoxy-3'-prenylnaringenin (12) revealed potent cytotoxicities against one or more cell lines with IC50 values in the range of 4.5-9.9 μM. | |
| IUPAC name | [(5R,7R,8R,9R,10R,13S,17R)-17-(2-hydroxy-5-oxo-2H-furan-3-yl)-4,4,8,10,13-pentamethyl-3-oxo-5,6,7,9,11,12,16,17-octahydrocyclopenta[a]phenanthren-7-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Limonoid | |
| Source of phytochemicals or plant Extracts | Azadirachta indica | |
| Geographical availability | Assam, Bangladesh, Cambodia, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer, Gastric cancer, Lung cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 8.3±0.5 μM against SKBR-3 | |
| Potency | In addition, evaluation of their cytotoxic activities against HL60, A549, AZ521, and SK-BR-3 human cancer cell lines, isoazadironolide (1), 4'-O-methyl-8-prenylnaringenin (5), euchrestaflavanone A (8), 9, and 3-methoxy-3'-prenylnaringenin (12) revealed potent cytotoxicities against one or more cell lines with IC50 values in the range of 4.5-9.9 μM. | |
| Cell line/ mice model | HL60, A549, AZ521, SKBR-3 | |
| Additional information | NA | |
| PubChem ID | 10814145 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1213180-2 | |
| Safety | NA |