| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-692 | |
| Phytochemical name or plant extracts | Isoasarone | |
| PMID | 29174417 | |
| Literature evidence | Phenylpropanoids isolated from Piper sarmentosum Roxb. induce apoptosis in breast cancer cells through reactive oxygen species and mitochondrial-dependent pathways. | |
| IUPAC name | 1,2,4-trimethoxy-5-prop-2-enylbenzene | |
| Phytochemicals’ class or type of plant extracts | Phenylpropanoids | |
| Source of phytochemicals or plant Extracts | Piper sarmentosum | |
| Geographical availability | Andaman Is., Borneo, Cambodia, China South-Central, China Southeast, Hainan, Jawa, Laos, Malaya, Maluku, Myanmar, New Guinea, Northern Territory, Philippines, Queensland, Sumatera, Thailand, Tibet, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax | |
| Gene or Protein evidence | Quantitative PCR results of MDA-MB-231 treated with asaricin (1) and isoasarone (2) showed altered expression of Bcl-2: Bax level. | |
| Target pathways | extrinsic, death receptor-linked caspase-8 pathway | |
| IC50 | 5.82 ± 0.78 µg/ml against MDA-MB-231 | |
| Potency | Isoasarone (2) markedly elevated caspase -8 and -3/7 activities and caused a decline in nuclear NF-κB translocation, suggesting extrinsic, death receptor-linked apoptosis pathway. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Both compounds increase reactive oxygen species (ROS), decrease mitochondrial membrane potential (MMP) and enhance cytochrome c release in treated MDA-MB-231 cells. | |
| PubChem ID | 636750 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:683278-2 | |
| Safety | NA |