| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1793 | |
| Phytochemical name or plant extracts | Iris Nertschinskia extract | |
| PMID | 23464484 | |
| Literature evidence | Iris Nertschinskia ethanol extract differentially induces cytotoxicity in human breast cancer cells depending on AKT1/2 activity. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Iris Nertschinskia | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT1, AKT2 | |
| Gene or Protein evidence | Knockdown of endogenous AKT1 or AKT2 in breast cancer cells by RNA interference determined the sensitivity to I. nertschinskia ethanol extract compared to control cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The I. nertschinskia ethanol extract induced cell death in a manner that depended on the level of phosphorylated AKT1/2 protein and was associated with a significant increase in the sub-G1 cell population, indicative of apoptosis. | |
| Cell line/ mice model | Hs578Tand MDA-MB-231 | |
| Additional information | we reported that an ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |