| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1855 | |
| Phytochemical name or plant extracts | Indole diketopiperazines | |
| PMID | 25787158 | |
| Literature evidence | Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diketopiperazines | |
| Source of phytochemicals or plant Extracts | Endophytic Chaetomium sp 88194 | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Chaetocochins G displayed more potent cytotoxicity in MCF-7 cells than the common chemotherapeutic agent (5-fluorouracil) associated with G2/M cell cycle arrest. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | To identify new antitumor agents, secondary metabolites of fungus Chaetomium sp 88194 were investigated and three new indole diketopiperazines, Chaetocochins G (1), Oidioperazines E (2) and Chetoseminudin E (3), along with two known compounds Chetoseminudins C (4) and N-acetyl-β-oxotryptamine (5), were obtained. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |