| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1628 | |
| Phytochemical name or plant extracts | Indole[3,2-b] carbazole | |
| PMID | 23179357 | |
| Literature evidence | I3C and ICZ inhibit migration by suppressing the EMT process and FAK expression in breast cancer cells. | |
| IUPAC name | indolo[3,2-b]carbazole | |
| Phytochemicals’ class or type of plant extracts | Polycyclic aromatic hydrocarbon | |
| Source of phytochemicals or plant Extracts | Cruciferous vegetables | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Vimentin, E-cadherin, MMP2, MMP9, FAK | |
| Gene or Protein evidence | In addition, I3C and ICZ decreased vimentin (a mesenchymal marker) and focal adhesion kinase (FAK) mRNA expression, while increasing E-cadherin (an epithelial marker) expression. Matrix metalloproteinase (MMP)-2 and -9 activity was also reduced by I3C and ICZ. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our findings suggested that I3C and ICZ are potential compounds for inhibition of breast cancer cell migration. | |
| Cell line/ mice model | MCF-7 and MDA-MB-231 | |
| Additional information | ICZ levels of 10 μM significantly suppressed MMP-9 and -2 activity by 47 and 72%, respectively, compared to untreated control cells. | |
| PubChem ID | 114764 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |