| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1245 | |
| Phytochemical name or plant extracts | Icaritin | |
| PMID | 28529129 | |
| Literature evidence | Our results thus indicated that icaritin has a potential to be developed into a novel therapeutic agent for human TNBC. | |
| IUPAC name | 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Epimedium diphyllum | |
| Geographical availability | Japan | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Liver cancer, Kidney cancer | |
| Target gene or protein | EGFR, GPER1 | |
| Gene or Protein evidence | Our study demonstrated that icartin decreased both ER-?36 and EGFR protein expression, and induced apoptosis in TNBC MDA-MB-231 and MDA-MB-453 cells. To the best of our knowledge, our current findings demonstrate for the first time that ICA and ICT promote the progression of ER-negative breast cancer through the activation of membrane GPER1. | |
| Target pathways | We also found that icaritin inhibited ER-?36-mediated MAPK/ERK pathway and cyclin D1 induction by estrogen. Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway. An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells. | |
| IC50 | NA | |
| Potency | Our results thus indicated that icaritin has a potential to be developed into a novel therapeutic agent for human TNBC. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, MDA-MB-453 , 4T1,SKBR-3 | |
| Additional information | Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC). | |
| PubChem ID | 5318980 | |
| Additional PMIDs | 23977023 24718680 26079090 32003229 32762483 25531867 21376032 28529129 | |
| Additional sources of information | https://www.drugbank.ca/drugs/DB12672 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:107274-1 | |
| Safety | NA |