| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-35 | |
| Phytochemical name or plant extracts | Icariin | |
| PMID | 34195430 | |
| Literature evidence | Cytotoxic activity of Icariin and Baicalein evaluated against MCF-7 cells revealed their potent activity with an IC50 of 42.15 ± 4.78 μg/ml and 44.37 ± 3.46 μg/ml, respectively, while very least effect was observed on normal cells (L6). | |
| IUPAC name | 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Alseodaphne semecarpifolia | |
| Geographical availability | India, Sri Lanka | |
| Plant parts | Stem, bark, leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERK1/2 | |
| Gene or Protein evidence | Our data also demonstrated that ICA and ICT increased the phosphorylation of ERK1/2. | |
| Target pathways | Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway. | |
| IC50 | 42.15 ± 4.78 μg/ml against MCF-7 | |
| Potency | Present study has suggested that both Icariin and Baicalein have potent cytotoxic activity against MCF-7 cells. | |
| Cell line/ mice model | SKBR-3, MCF-7, MCF-7/TAM | |
| Additional information | Icariin is pharmacologically active prenylated flavonoid glycoside that has various biologic effects such as antioxidant, anticancer, and anti-inflammatory activities. Icariin abrogates osteoclast formation through the regulation of the RANKL-mediated TRAF6/NF-κB/ERK signaling pathway in Raw264.7 cells. Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM. | |
| PubChem ID | 5318997 | |
| Additional PMIDs | 15739900 24718680 30466615 31172425 15541416 32476145 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:462510-1 | |
| Safety | Cytotoxic activity of Icariin and Baicalein evaluated against MCF-7 cells revealed their potent activity with an IC50 of 42.15 ± 4.78 μg/ml and 44.37 ± 3.46 μg/ml, respectively, while very least effect was observed on normal cells (L6). |