| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1854 | |
| Phytochemical name or plant extracts | Icacinlactone F | |
| PMID | 25782063 | |
| Literature evidence | Compounds 1-7, as well as four known related structures, were evaluated for cytotoxic activity against MDA-MB-435 (human melanoma cancer), MDA-MB-231 (human breast cancer), and OVCAR3 (human ovarian cancer) cell lines. | |
| IUPAC name | (1R,2S,10S,12R,15R,16R,21R)-10,16-dihydroxy-15-methyl-8,13,17-trioxahexacyclo[14.2.2.11,12.02,10.05,9.015,21]henicosa-5(9),6-diene-4,14-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Icacina trichantha | |
| Geographical availability | Benin, Nigeria | |
| Plant parts | Tuber | |
| Other cancers | Breast cancer, Skin cancer, Ovarian cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 8.94 μM against MDA-MB-231 6.16 μM against MDA-MB-435 | |
| Potency | Icacinlactone F (6) displayed moderate cytotoxic activity in the MDA-MB-435 cells (IC50 6.16 μM). In the MDA-MB-231 cells | |
| Cell line/ mice model | MDA-MB-435, MDA-MB-231, OVCAR3 | |
| Additional information | NA | |
| PubChem ID | 122178835 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:607933-1 | |
| Safety | NA |