| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-502 | |
| Phytochemical name or plant extracts | Hyperoside | |
| PMID | 32447047 | |
| Literature evidence | Thus, hyperoside may elevate breast cancer cell sensitivity to paclitaxel by blocking TLR4 activation-mediated pro-inflammatory and pro-survival approaches, thereby endorsing its usefulness as a promising therapeutic combination to overcome chemosensitivity in breast cancer. | |
| IUPAC name | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Lotus ucrainicus | |
| Geographical availability | Central European Rus, East European Russia, Krym, Northwest European R, South European Russi, Ukraine | |
| Plant parts | NA | |
| Other cancers | NA | |
| Target gene or protein | Bcl-2, Bax, IL-6 | |
| Gene or Protein evidence | Concomitantly, hyperoside also attenuated paclitaxel-mediated anti-apoptotic Bcl-2 expression, but enhanced the effects of paclitaxel on pro-apoptotic Bax expression, and pro-inflammatory cytokine IL-6 and IL-6 levels in MDA-MB-231 cells. | |
| Target pathways | TLR4-NF-κB signaling | |
| IC50 | NA | |
| Potency | Intriguingly, paclitaxel stimulation activated the TLR4-NF-κB signaling, which was reversed after hyperoside administration. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Thus, hyperoside may elevate breast cancer cell sensitivity to paclitaxel by blocking TLR4 activation-mediated pro-inflammatory and pro-survival approaches, thereby endorsing its usefulness as a promising therapeutic combination to overcome chemosensitivity in breast cancer. | |
| PubChem ID | 5281643 | |
| Additional PMIDs | 17608228 26437391 28284186 32447047 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:503938-1 | |
| Safety | Hyperoside exhibited little cytotoxicity to normal human breast mammary epithelial cell lines, and also protected against paclitaxel-induced cytotoxicity in MCF-10A. |