| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-373 | |
| Phytochemical name or plant extracts | Hypericum salsugineum extracts | |
| PMID | 29864137 | |
| Literature evidence | Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Hypericum salsugineum | |
| Geographical availability | Turkey | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Colorectal cancer | |
| Target gene or protein | Tyrosinase | |
| Gene or Protein evidence | The extracts exhibited good inhibitory effects on tyrosinase and glucosidase, while they had weak ability against cholinesterases and amylase. | |
| Target pathways | Focusing on recent breast cancer research, Jiao et al. reported that, myricetin suppressed the cell viability of MCF-7 cells mainly through p21-activated kinase 1 through downstream signaling of the β-catenin pathway. In another study, Ranganathan et al. demonstrated that quercetin induces apoptosis in breast cancer cells through suppression of Twist via p38MAPK pathway | |
| IC50 | 365.3±19.2 μg/ml against MCF-7 368±4.2 μg/ml against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | H. salsugineum contains chlorogenic acid derivatives as major phenolic compounds, and myricetin and quercetin derivatives as major flavonols. We believe that the inhibition effects of H. salsugineum on breast cancer cell lines are due to the compounds that we have identified. H. salsugineum contains chlorogenic acid derivatives as major phenolic compounds, and myricetin and quercetin derivatives as major flavonols. All these phenolic compounds’ chemopreventive properties and mechanisms of action are well-described in the literature. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:433827-1 | |
| Safety | NA |