| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2180 | |
| Phytochemical name or plant extracts | Hypericum adenotrichum extract | |
| PMID | 26617407 | |
| Literature evidence | At selected doses (125-500 μg/ml), the H. adenotrichum extract exhibited significant genotoxic activity in human lymphocytes, whereas it showed anti-growth effects on cancer cell lines between 0.2 and 100 μg/ml concentrations. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Hypericum adenotrichum | |
| Geographical availability | Turkey | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, PARP | |
| Gene or Protein evidence | he mode of cell death in cancer cells was shown to be apoptosis due to the presence of pyknotic nuclei, the cleavage of poly-(ADP-ribose) polymerase (PARP) and/or the activation of caspase-3. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | At selected doses (125-500 μg/ml), the H. adenotrichum extract exhibited significant genotoxic activity in human lymphocytes, whereas it showed anti-growth effects on cancer cell lines between 0.2 and 100 μg/ml concentrations. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | These results suggest that H. adenotrichum might show both cytotoxic and genotoxic effects depending on the cell type. This should be taken into account in its use for therapeutic purposes. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:433156-1 | |
| Safety | NA |