| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-257 | |
| Phytochemical name or plant extracts | Hyperforin | |
| PMID | 11850844 | |
| Literature evidence | Owing to the combination of significant antitumour activity, low toxicity in vivo and natural abundance of the compound, hyperforin holds the promise of being an interesting novel antineoplastic agent that deserves further laboratory and in vivo exploration. | |
| IUPAC name | (1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione | |
| Phytochemicals’ class or type of plant extracts | Monoterpenoid | |
| Source of phytochemicals or plant Extracts | Hypericum undulatum | |
| Geographical availability | Algeria, Azores, France, Great Britain, Ireland, Madeira, Morocco, Portugal, Spain | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ER1 | |
| Gene or Protein evidence | Ingenuity pathway analysis also demonstrated that hyperforin treatment induced less cell proliferation than 17β-estradiol by downregulating estrogen receptor 1. | |
| Target pathways | Mitochondria-mediated apoptosis pathway | |
| IC50 | 1.50 μg/m against MCF-7 2.00 μg/ml against MDA-MB-468 | |
| Potency | NA | |
| Cell line/ mice model | A431 ,SB1 ,SB3 ,MV3 ,1F6 ,HT144 ,Jurkat ,MCF-7 ,MDA-MB-468 ,SK-OV-3 | |
| Additional information | In conclusion, although, hyperforin exhibited lower estrogenic activity than 17β-estradiol, the compound induced lower levels of cancer cell proliferation in vitro. | |
| PubChem ID | 441298 | |
| Additional PMIDs | 11850844 27454708 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:325121-2 | |
| Safety | NA |