| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-418 | |
| Phytochemical name or plant extracts | Hydroxytyrosol | |
| PMID | 31333142 | |
| Literature evidence | As such, novel chemotherapeutic agents are urgently needed, especially for Triple-Negative Breast Cancer (TNBC). | |
| IUPAC name | 4-(2-hydroxyethyl)benzene-1,2-diol | |
| Phytochemicals’ class or type of plant extracts | Catechol | |
| Source of phytochemicals or plant Extracts | Teucrium polium | |
| Geographical availability | Algeria, Corse, France, Morocco, Spain, Tunisia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Beclin-1, p62 | |
| Gene or Protein evidence | Moreover, HT or OL treatment significantly suppressed HGF or 3-MA induced cell migration and invasion by reversing LC3-II/LC3-I and Beclin-1 downregulation and reversing p62 upregulation. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | MDAMB- 231 cells were more sensitive to HT treatment than OL treatment. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | These data indicated that HT and OL may inhibit migration and invasion of TNBC cells by activating autophagy. These findings provide potential therapeutic strategies that target autophagy to limit the pathogenesis and progression of BC. | |
| PubChem ID | 82755 | |
| Additional PMIDs | 31151435 26434999 24691968 31514476 24727461 29468462 35057436 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:460631-1 | |
| Safety | NA |