| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-962 | |
| Phytochemical name or plant extracts | Houttuyninum | |
| PMID | 22525372 | |
| Literature evidence | SIGNIFICANCE: Our findings showed that houttuyninum can inhibit the HER2/neu signalling pathway and the tumor growth of cancer cells that overexpress HER2/neu. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Houttuynia cordata | |
| Geographical availability | Assam, Bangladesh, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, Japan, Korea, Myanmar, Nepal, Ogasawara-shoto, Taiwan, Thailand, Tibet, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERK1/2, AKT | |
| Gene or Protein evidence | Houttuyninum also inhibited the activation of ERK1/2 and AKT | |
| Target pathways | HER2/neu signalling pathway | |
| IC50 | 5.52 μg/ml against MDA-MB-453 | |
| Potency | Houttuyninum inhibited phosphorylation of HER2 in a dose-dependent manner with an IC50 of 5.52 μg/ml without reducing HER2/neu protein expression in MDA-MB-453 cells. | |
| Cell line/ mice model | MDA-MB-468, BT-474, A431, N87 xenografts | |
| Additional information | Our findings showed that houttuyninum can inhibit the HER2/neu signalling pathway and the tumor growth of cancer cells that overexpress HER2/neu. This drug may provide therapeutic value in the treatment of cancers that involve overexpression of HER2/neu. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:927252-1 | |
| Safety | NA |