| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-142 | |
| Phytochemical name or plant extracts | Hispidulin | |
| PMID | 33552273 | |
| Literature evidence | Overall, the current findings suggested that hispidulin may inhibit EMT and cell migration by suppressing the Smad2/3 signaling pathway in breast cancer cells. | |
| IUPAC name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Dittrichia viscosa | |
| Geographical availability | Albania, Algeria, Azores, Baleares, Bulgaria, Canary Is., Corse, Cyprus, East Aegean Is., Egypt, France, Greece, Italy, Kriti, Lebanon-Syria, Libya, Madeira, Morocco, Palestine, Portugal, Sardegna, Sicilia, Sinai, Spain, Tunisia, Turkey, Turkey-in-Europe, Yugoslavia | |
| Plant parts | Stem, Leaves, Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | Vimentin , E-cadherin, occludin | |
| Gene or Protein evidence | However, hispidulin and TGF-β1 co-treatment increased the expression levels of E-cadherin and occludin, while downregulating vimentin expression. Additionally, hispidulin treatment inhibited TGF-β1-induced Smad2/3 signaling and cell migration in both breast cancer cell lines. | |
| Target pathways | Smad2/3 signaling pathway | |
| IC50 | 25.44±0.23 µM against MCF-7 | |
| Potency | Overall, the current findings suggested that hispidulin may inhibit EMT and cell migration by suppressing the Smad2/3 signaling pathway in breast cancer cells. | |
| Cell line/ mice model | MCF-7, HCC38 | |
| Additional information | Hispidulin treatment increased the expression levels of EMT-associated epithelial markers and decreased the expression levels of mesenchymal markers in both cells. Transforming growth factor-β1 (TGF-β1) treatment increased breast cancer cell viability (assessed via MTS assay) and EMT induction. | |
| PubChem ID | 5281628 | |
| Additional PMIDs | 34015367 23561091 22537643 33552273 22418930 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:201893-1 | |
| Safety | NA |