| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-177 | |
| Phytochemical name or plant extracts | Hinokitiol | |
| PMID | 27073579 | |
| Literature evidence | Hinokitiol may act as an anti-VM agent, and may be useful for the development of novel breast cancer therapeutic agents. | |
| IUPAC name | 2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one | |
| Phytochemicals’ class or type of plant extracts | Monoterpenoid | |
| Source of phytochemicals or plant Extracts | Chamaecyparis obtusa | |
| Geographical availability | Japan, Taiwan | |
| Plant parts | Heartwood | |
| Other cancers | Breast cancer | |
| Target gene or protein | EGFR | |
| Gene or Protein evidence | Hinokitiol was additionally indicated to downregulate EGFR protein expression in mammosphere-forming BCSCs without affecting the expression of messenger RNA. | |
| Target pathways | NA | |
| IC50 | 46.6±7.5 µM against MDA-MB-231 | |
| Potency | Hinokitiol may act as an anti-VM agent, and may be useful for the development of novel breast cancer therapeutic agents. | |
| Cell line/ mice model | AS-B244, MDA-MB-231 | |
| Additional information | In conclusion, the present study indicated that hinokitiol may inhibit the VM activity of BCSCs through stimulating proteasome-mediated EGFR degradation. | |
| PubChem ID | 3611 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:263878-1 | |
| Safety | NA |