| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-577 | |
| Phytochemical name or plant extracts | Hibiscus syriacus extract | |
| PMID | 25885960 | |
| Literature evidence | H. syriacus extracts may provide important insight into the development of novel alternative therapies for breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Hibiscus syriacus | |
| Geographical availability | China South-Central, China Southeast, Taiwan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT | |
| Gene or Protein evidence | H. syriacus extracts might inhibit breast cancer cell viability and induce apoptosis by activating p53 family regulated pathways and inhibiting AKT activation. | |
| Target pathways | p53 family regulated pathways | |
| IC50 | NA | |
| Potency | We found several triterpenoids including betulin (K02) and its derivatives (K03, K04, and K06) from H. syriacus inhibited human triple-negative breast cancer cell viability and migration but revealed smaller cytotoxic effects on normal mammalian epithelial cells. | |
| Cell line/ mice model | MDA-MB-231, HBL-100 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 28534383 25885960 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:560890-1 | |
| Safety | NA |