| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1685 | |
| Phytochemical name or plant extracts | Hibiscus rosa-sinesis extract | |
| PMID | 31060537 | |
| Literature evidence | RESULTS: Hibiscus extract was able to selectively induce apoptosis in both triple-negative and estrogen-receptor positive breast cancer cells in a dosage-dependent manner. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Hibiscus rosa-sinesis | |
| Geographical availability | Toronto, ON, Canada | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | We have shown that HE treatment has the potential to be used alongside tamoxifen, taxol, and cisplatin treatments without any inhibition of drug potency. | |
| Cell line/ mice model | MDA-MB-231 and MCF-7 cells | |
| Additional information | Hibiscus extract was able to selectively induce apoptosis in both triple-negative and estrogen-receptor positive breast cancer cells in a dosage-dependent manner. Most importantly, addition of hibiscus extract was found to enhance the induction of apoptosis of chemotherapy treatments (taxol and cisplatin) in triple-negative breast cancer cells when compared to treatment alone. Moreover, hibiscus extract addition to chemotherapy treatment was able to increase oxidative stress and decrease mitochondrial membrane potential compared to individual treatments. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |