| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1320 | |
| Phytochemical name or plant extracts | Hibiscus extract | |
| PMID | 31060537 | |
| Literature evidence | RESULTS: Hibiscus extract was able to selectively induce apoptosis in both triple-negative and estrogen-receptor positive breast cancer cells in a dosage-dependent manner. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Hibiscus syriacus | |
| Geographical availability | China South-Central, China Southeast, Taiwan | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21 | |
| Gene or Protein evidence | They activated p21 expression, which induced cell cycle arrest in breast cancer cells. | |
| Target pathways | H. syriacus extracts might inhibit breast cancer cell viability and induce apoptosis by activating p53 family regulated pathways and inhibiting AKT activation. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HBL-100 and normal human skin fibroblast cell line. | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 28160848 25885960 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:560890-1 | |
| Safety | NA |