| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-253 | |
| Phytochemical name or plant extracts | Hibifolin | |
| PMID | 17323972 | |
| Literature evidence | Among these flavonoids, baicalein, scutellarin, hibifolin, and quercetin-3'-glucoside possessed the strongest effect in neuroprotection, however, the neuroprotective activity did not directly correlate with the estrogenic activity of the flavonoids. | |
| IUPAC name | (2S,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-oxochromen-8-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Helicteres isora | |
| Geographical availability | Andaman Is., Bangladesh, Cambodia, China South-Central, Hainan, India, Laos, Malaya, Maluku, Myanmar, Nepal, Pakistan, Sri Lanka, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | First, the estrogenic activities of these flavonoids were determined by activating the estrogen-responsive elements in cultured MCF-7 breast cancer cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Hibifolin protected neurons against A beta-induced apoptosis and stimulated Akt activation, which would be useful in developing potential drugs or food supplements for treating AD. | |
| PubChem ID | 5490334 | |
| Additional PMIDs | 19539722 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:321222-2 | |
| Safety | NA |