| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1601 | |
| Phytochemical name or plant extracts | Hesperidin | |
| PMID | 33360419 | |
| Literature evidence | Bioinformatics analysis revealed about 75 potential therapeutic target proteins of HES in BCSCs (TH), in which TP53 was the only direct target protein (DTP) with a high degree score. | |
| IUPAC name | (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Yucca aloifolia variegata | |
| Geographical availability | Alabama, Bermuda, Florida, Georgia, Louisiana, Mexico Central, Mexico Gulf, Mexico Southeast, Mexico Southwest, Mississippi, North Carolina, South Carolina, Texas, Virginia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | p21, Cyclin D1, p53 | |
| Gene or Protein evidence | In addition, HES treatment reduced the mRNA level of p21 but increased the mRNA level of cyclin D1 and p53 in the mammosphere. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | It is concluded that hesperidin can inhibit the proliferation of breast cancer cells through mechanisms other than antimitosis and it is suggested that hesperidin be further investigated for the possible interaction with androgenic receptors and involvement in signaling pathway after receptor binding in prostate cancer cells through future research. | |
| Cell line/ mice model | MCF-7, HepG2, MDA-MB-231 | |
| Additional information | These chemotherapeutic and chemosensitising activities of hesperidin and hesperetin have been linked to several mechanisms, including the modulation of signalling pathways, glucose uptake, enzymes, miRNA expression, oxidative status, cell cycle regulatory proteins, tumour suppressor p53, plasma and liver lipid profiles as well as DNA repair mechanisms. | |
| PubChem ID | 10621 | |
| Additional PMIDs | 31979178 32208740 8721977 32518242 19548283 34866972 34368589 23562496 29304552 28539711 32084471 29981677 34681416 33360419 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:325009-2 | |
| Safety | NA |