| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-338 | |
| Phytochemical name or plant extracts | Herbacetin | |
| PMID | 26297979 | |
| Literature evidence | Treatment with Herbacetin decreased the release of proinflammatory cytokines, including TNF-α and IL-1β. Moreover, Herbacetin inhibited the activity of JNK kinase and nuclear factor-κB, signaling molecules involved in NO production. | |
| IUPAC name | 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Ephedra sinica | |
| Geographical availability | Buryatiya, Chita, Irkutsk, Mongolia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | TNF-α , IL-1β, JNK, NF-κB, c-met, AKT | |
| Gene or Protein evidence | Treatment with Herbacetin decreased the release of proinflammatory cytokines, including TNF-α and IL-1β. Moreover, Herbacetin inhibited the activity of JNK kinase and nuclear factor-κB, signaling molecules involved in NO production. Herbacetin suppressed hepatocyte growth factor-induced motility in human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation and directly inhibiting c-Met tyrosine kinase activity. | |
| Target pathways | JNK and NF-κB signaling pathways | |
| IC50 | NA | |
| Potency | These findings suggest that Herbacetin exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators. | |
| Cell line/ mice model | MDA-MB-231, HepG2, RAW 264.7 | |
| Additional information | Moreover, Herbacetin inhibited the activity of JNK kinase and nuclear factor-κB, signaling molecules involved in NO production. Cell signaling analysis using Bay 11-7082 (an inhibitory κB kinase 2 inhibitor) and mitogen-activated protein kinase (MAPK) inhibitors (SB203580 for p38, SP600125 for JNK, and PD 98059 for ERK) suggested that LPS induced iNOS expression via activation of the JNK and NF-κB pathway, but not the p38 and ERK pathway. | |
| PubChem ID | 5280544 | |
| Additional PMIDs | 24081687 26297979 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:383378-1 | |
| Safety | NA |