| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-147 | |
| Phytochemical name or plant extracts | Helenalin | |
| PMID | 25435410 | |
| Literature evidence | A recent study used the PLGA-PEG-helenalin complex, and free helenalin, to inhibit the expression of telomerase in the breast cancer cell line. | |
| IUPAC name | (3aR,5R,5aR,8aR,9S,9aS)-9-hydroxy-5,8a-dimethyl-1-methylidene-3a,4,5,5a,9,9a-hexahydroazuleno[6,7-b]furan-2,8-dione | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Psilostrophe cooperi | |
| Geographical availability | Arizona, California, Mexico Northwest, Nevada, Utah | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Telomerase | |
| Gene or Protein evidence | This finding has been proved through the decrease of telomerase gene expression by real-time PCR. | |
| Target pathways | NA | |
| IC50 | 1.3 μM against T47D for 72h | |
| Potency | In this study, we demonstrated that the NC-helenalin complex is more effective than free helenalin in inhibiting the growth of breast cancer cells. | |
| Cell line/ mice model | T47D | |
| Additional information | The nuclear factor-kappaB (NF-kappaB)-DNA binding inhibitor helenalin (20 microM) also prevented induction. | |
| PubChem ID | 23205 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:212091-2 | |
| Safety | NA |