| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1086 | |
| Phytochemical name or plant extracts | Hawthorn fruit (HF) extract | |
| PMID | 28284186 | |
| Literature evidence | Phytochemical compositions of extract from peel of hawthorn fruit, and its antioxidant capacity, cell growth inhibition, and acetylcholinesterase inhibitory activity. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Peel polyphenolic extract (HPP) and flesh polyphenolic extract (HFP) | |
| Source of phytochemicals or plant Extracts | Crataegus pinnatifida | |
| Geographical availability | Amur, China North-Central, China Southeast, Inner Mongolia, Khabarovsk, Korea, Manchuria, Primorye | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Ovarian cancer | |
| Target gene or protein | Caspase 3, Caspase 9 | |
| Gene or Protein evidence | Flow cytometric analysis revealed that both HPP and HFP mediated the cell-cycle arrest at the S-phase, and also dose-dependently led to apoptosis of MCF-7 cells via the mitochondrial pathway, as evidenced by the activation of caspase-3 and caspase-9 and the elevation of intracellular ROS production. | |
| Target pathways | NA | |
| IC50 | 2.76 μg/mL against MCF-7 | |
| Potency | ll these findings indicate that hawthorn fruit, especially its peel, is an excellent source of natural chemopreventive agents in the treatment of breast cancer. | |
| Cell line/ mice model | MCF-7, SKOV-3 | |
| Additional information | In China, hawthorn fruit (HF) has the effects of improving digestion and regulating qi-flowing for removing blood stasis. | |
| PubChem ID | NA | |
| Additional PMIDs | 23790880 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:724002-1 | |
| Safety | NA |