| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-368 | |
| Phytochemical name or plant extracts | Halophila ovalis extract | |
| PMID | 32238022 | |
| Literature evidence | The marine ecosystem is considered as a treasure of numerous novel biologically active molecules. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Phenolic extract | |
| Source of phytochemicals or plant Extracts | Halophila ovalis | |
| Geographical availability | Andaman Is., Borneo, Cape Provinces, Caroline Is., China Southeast, Comoros, Egypt, Eritrea, Fiji, Gulf States, Hainan, India, Iran, Japan, Jawa, Kenya, Kuwait, KwaZulu-Natal, Lesser Sunda Is., Madagascar, Malaya, Maluku, Mauritius, Mozambique, Myanmar, Nansei-shoto, New Caledonia, New Guinea, New South Wales, Nicobar Is., Norfolk Is., Northern Territory, Oman, Pakistan, Palestine, Philippines, Queensland, Rodrigues, Samoa, Saudi Arabia, Seychelles, Society Is., Solomon Is., Somalia, South China Sea, Sri Lanka, Sudan, Sulawesi, Taiwan, Tanzania, Thailand, Tonga, Vietnam, Western Australia, Yemen | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, PARP, Nrf-2, SOD-2, HO-1, Caspase 3 | |
| Gene or Protein evidence | The protein expression analyzes show decreased expression of the anti-apoptotic protein, Bcl-2, and DNA repair enzyme, PARP in treated cells indicating the probable molecular targets of apoptosis. Further, the phenolic extract of H. ovalis blocked the antioxidant defense system in MCF-7 cells by down-regulating the protein expression of a major transcription factor, Nrf-2 and regulatory antioxidant enzymes, SOD-2 and HO-1. An increased expression of the active fragments of an executioner caspase, caspase 3 in phenolic extract-treated MCF-7 cells further confirms this apoptosis induction. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results show the presence of chemopreventive compound(s) in the phenolic extract, which offers a platform for future studies to identify the active principles. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | An increased expression of the active fragments of an executioner caspase, caspase 3 in phenolic extract-treated MCF-7 cells further confirms this apoptosis induction. In consequence, the loss of mitochondrial membrane potential was noticed in treated cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:431761-1 | |
| Safety | NA |