| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1972 |
| Phytochemical name or plant extracts | Gyrophoric acid |
| PMID | 20837130 |
| Literature evidence | One of the ways for searching for potentially new anti-cancer drugs is the testing of various naturally synthesized compounds. |
| IUPAC name | 4-[4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoyl]oxy-2-hydroxy-6-methylbenzoic acid |
| Phytochemicals’ class or type of plant extracts | Carbonyl compound |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | Lichen |
| Other cancers | Breast cancer, Cervical cancer, Liver cancer, Ovarian cancer, Leukemia |
| Target gene or protein | NA |
| Gene or Protein evidence | NA |
| Target pathways | NA |
| IC50 | >200 μM against MCF-7 and SK-BR-3 |
| Potency | Our study reports on the sensitivity of up to nine human cancer cell lines (A2780, HeLa, MCF-7, SK-BR-3, HT-29, HCT-116 p53(+/+), HCT-116 p53(-/-), HL-60 and Jurkat) to the anti-proliferative/cytotoxic effects of four typical secondary metabolites of lichens (parietin, atranorin, usnic acid and gyrophoric acid). |
| Cell line/ mice model | A2780, HeLa, MCF-7, SKBR-3, HT-29, HCT-116 p53(+/+), HCT-116 p53(-/-), HL-60 and Jurkat |
| Additional information | NA |
| PubChem ID | 135728 |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |