| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-197 | |
| Phytochemical name or plant extracts | Gypenoside 5 | |
| PMID | 20555000 | |
| Literature evidence | Recently, Gyp has been shown to induce cell cycle arrest and apoptosis in many human cancer cell lines. | |
| IUPAC name | (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid saponin | |
| Source of phytochemicals or plant Extracts | Gynostemma pentaphyllum | |
| Geographical availability | Assam, Bangladesh, Borneo, China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, Japan, Jawa, Korea, Kuril Is., Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nansei-shoto, Nepal, New Guinea, Philippines, Sri Lanka, Sulawesi, Sumatera, Thailand, Vietnam, West Himalaya | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | Tyrosine phosphatase 1B | |
| Gene or Protein evidence | Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC50 value of 8.2 ± 0.9 μM | |
| Target pathways | NA | |
| IC50 | 10.5 ± 1.4 to 14.2 ± 2.6 μM against MCF7, MCF7/ADR, MDA-MB-231 | |
| Potency | Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC50 value of 8.2 ± 0.9 μM, and moderate cytotoxicity against human breast cancer cells MCF7, MCF7/ADR, and MDA-MB-231, with IC50 values ranging from 10.5 ± 1.4 to 14.2 ± 2.6 μM. | |
| Cell line/ mice model | MCF-7, MCF-7/ADR, MDA-MB-231 | |
| Additional information | The results from real-time PCR analysis indicated that treatment of SAS cells with 180 mug/ml of Gyp for 24 h led to a decrease in 14-3-3sigma, DNA-dependent serine/threonine protein kinase (DNAPK), p53, ataxia telangiectasia mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and breast cancer gene 1 (BRCA1) mRNA expression. | |
| PubChem ID | 24721561 | |
| Additional PMIDs | 28662582 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:292905-1 | |
| Safety | NA |