| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1655 |
| Phytochemical name or plant extracts | Guizhi Fuling Decoction (GFD) |
| PMID | 28392270 |
| Literature evidence | It was found that, with exception of 1, all the tested compounds could inhibit cell proliferation in TGF-β1 induced NRK-49F cells with compounds 2 being most active. |
| IUPAC name | NA |
| Phytochemicals’ class or type of plant extracts | composed of 5 herbs, including Cinnamomi Ramulus (Guizhi), Poria (Fuling), Radix Paeoniae Rubra (Chishao), Cortex Moutan (Mudanpi), and Persicae Semen (Taoren) |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | China |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | HRAS, EGFR, PTK2, SOS1, ITGB1 |
| Gene or Protein evidence | Meanwhile, experimental analysis was carried out to examine changes in the expression levels of 308 genes involved in the "pathways in cancer" in BRCA cells treated by five herbs of GFD utilizing HTS2 platform, and 5 key therapeutic targets, including HRAS, EGFR, PTK2, SOS1, and ITGB1, were identified. |
| Target pathways | PI3K and the MAPK signaling pathways |
| IC50 | NA |
| Potency | Besides, consistent with the TCM theory about the synergy of Cinnamomi Ramulus (Guizhi) by Cortex Moutan (Mudanpi) in GFD, both of these two herbs acted on the same targets and pathways. |
| Cell line/ mice model | MDA-MB-231 |
| Additional information | NA |
| PubChem ID | NA |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |