| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1349 | |
| Phytochemical name or plant extracts | Gugulipid | |
| PMID | 23914993 | |
| Literature evidence | Targeting beta-catenin signaling to induce apoptosis in human breast cancer cells by z-guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Lipid | |
| Source of phytochemicals or plant Extracts | Commiphora mukul | |
| Geographical availability | India, Oman, Pakistan, Yemen | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | TCF-4, Cyclin D1, C-myc, Survivin | |
| Gene or Protein evidence | The decreased expression of Wnt/β-Catenin targeting genes, such as cyclin D1, C-myc and survivin, and the inhibition of the activity of the transcription factor (T-cell factor 4, TCF-4) were observed in GL-treated breast cancer cells. | |
| Target pathways | β-Catenin signaling pathway | |
| IC50 | ~2 µM against MCF-7 and MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 198955982 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:127856-1 | |
| Safety | NA |