| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1283 | |
| Phytochemical name or plant extracts | Guggulsterone | |
| PMID | 17475222 | |
| Literature evidence | JNK was needed for guggulsterone-induced apoptosis, inasmuch as inhibition of JNK by pharmacological inhibitors or by genetic deletion of MKK4 (activator of JNK) abolished the activity. | |
| IUPAC name | (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione | |
| Phytochemicals’ class or type of plant extracts | 3-hydroxy steroid | |
| Source of phytochemicals or plant Extracts | Commiphora mukul | |
| Geographical availability | India, Oman, Pakistan, Yemen | |
| Plant parts | Gum resin | |
| Other cancers | Breast cancer, Head and neck cancer, Multiple myeloma, Lung cancer, Skin cancer, Ovarian cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | 1) Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. 2) The apoptosis induced by guggulsterone was also indicated by the activation of caspase-8, bid cleavage, cytochrome c release, caspase-9 activation, caspase-3 activation, and PARP cleavage. 3) The apoptotic effects of guggulsterone were preceded by activation of JNK and downregulation of Akt activity. 4) Overall, our results indicate that guggulsterone can inhibit cell proliferation and induce apoptosis through the activation of JNK, suppression of Akt, and downregulation of antiapoptotic protein expression. | |
| IC50 | NA | |
| Potency | CONCLUSION: Our in silico study has explored the possible chemopreventive mechanism of these phytochemicals against the NF-κB precursor protein p105 and deciphered that quercetin, 1-caffeoylquinic acid and guggulsterone were the potent inhibitors against target molecule. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HMEC | |
| Additional information | NA | |
| PubChem ID | 6450278 | |
| Additional PMIDs | 17475222 23661994 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:127738-1 | |
| Safety | NA |