| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1035 | |
| Phytochemical name or plant extracts | Grifolin | |
| PMID | 15949805 | |
| Literature evidence | Owing to the combination of the significant antitumor activity by inducing apoptosis and natural abundance of the compound, grifolin holds the promise of being an interesting antitumor agent that deserves further laboratory and in vivo exploration. | |
| IUPAC name | 5-methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Albatrellus confluens | |
| Geographical availability | NA | |
| Plant parts | Fruiting body | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | Bax, Bcl-2, Caspase 8, Caspase 9, Caspase 3, DAPK1 | |
| Gene or Protein evidence | The increase of caspase-8, 9, 3 activities revealed that caspase was a key mediator of the apoptotic pathway induced by grifolin, and the underexpression of Bcl-2 and up-regulation of Bax resulted in the increase of Bax: Bcl-2 ratio, suggesting that Bcl-2 family involved in the control of apoptosis. Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells. | |
| Target pathways | p53-DAPK1 pathway | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, HL-60, SMMC-7721, A-549 | |
| Additional information | We found that grifolin increased both Ser392 and Ser20 phosphorylation levels of transcription factor p53 protein, which could promote its transcriptional activity. | |
| PubChem ID | 5372312 | |
| Additional PMIDs | 20943371 15949800 24858140 | |
| Additional sources of information | NA | |
| Safety | NA |