| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1906 | |
| Phytochemical name or plant extracts | Grifola frondosa extract (GFPs) | |
| PMID | 28765878 | |
| Literature evidence | Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Grifola frondosa | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | All these findings revealed that GFPs induced human breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway | |
| IC50 | 335 µg/ml against MCF-7 412 µg/ml against MDA-MB-231 | |
| Potency | The potential anti-tumor effects of GPFs on breast cancer were successfully confirmed in MCF-7 and MDA-MB-231 cells, and tumor-bearing nude mice. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Moreover, the GFPs significantly suppressed the phosphorylation of AKT/glycogen synthase kinase-3β and extracellular signal-regulated kinases in a time-dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | 29805742 | |
| Additional sources of information | NA | |
| Safety | NA |