| Properties | Information1 | Information2 |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1365 | PhytoCAT-1933 |
| Phytochemical name or plant extracts | Graviola extract | Graviola extract |
| PMID | 30853648 | |
| Literature evidence | CONCLUSIONS: ionic liquid Graviola fruit extract affect the cytokinetics behaviour of MCF-7?cells by reducing cell viability, induce apoptosis and cell cycle arrest at the G0/G1 phase. | Graviola has various biological activities, and it is best known for its anticancer activity. |
| IUPAC name | NA | NA |
| Phytochemicals’ class or type of plant extracts | Ionic liquid extract | Aqueous extract |
| Source of phytochemicals or plant Extracts | Annona muricata | Annona muricata |
| Geographical availability | Belize, Bolivia, Colombia, Costa Rica, Ecuador, French Guiana, Guatemala, Guyana, Honduras, Mexico Southeast, Nicaragua, Panamá, Peru, Suriname, Venezuela | Belize, Bolivia, Colombia, Costa Rica, Ecuador, French Guiana, Guatemala, Guyana, Honduras, Mexico Southeast, Nicaragua, Panamá, Peru, Suriname, Venezuela |
| Plant parts | Fruits | Leaves |
| Other cancers | Breast cancer | Breast cancer |
| Target gene or protein | NA | EGFR |
| Gene or Protein evidence | NA | GFE significantly downregulated EGFR mRNA expression, arrested cell cycle in the G0/G1 phase, and induced apoptosis in MDA-MB-468 cells. |
| Target pathways | Both mechanisms either apoptosis and necrosis are induced by Graviola fruit ionic liquid extract | These data showed that dietary GFE induced significant growth inhibition of MDA-MB-468 cells in vitro and in vivo through a mechanism involving the EGFR/ERK signaling pathway |
| IC50 | 4.75 µg/mL against MCF-7 | 4.75 μg/mL against MCF-7 |
| Potency | NA | The crude extract of the graviola leaves induced mitochondrial apoptosis, suppressed cell proliferation, and decreased cellular motility in MDA-MB-231 TNBC cells. |
| Cell line/ mice model | MCF-7 | MDA-MB-231, MCF-7, MDA-MB-468 |
| Additional information | Ionic liquid Graviola fruit extract affect the cytokinetics behaviour of MCF-7 cells by reducing cell viability, induce apoptosis and cell cycle arrest at the G0/G1 phase. | The phytochemicals derived from graviola have various biological activities, including anticancer, antiarthritic, and antiparasitic activities |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:14308-2 | |
| Safety | NA | NA |