| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1726 | |
| Phytochemical name or plant extracts | Grape seed extract | |
| PMID | 19131542 | |
| Literature evidence | Depletion of polyphenol with polyvinylpyrrolidone abolished the inhibitory activity of GSE, suggesting a water-soluble fraction of polyphenol in GSE is responsible for the inhibitory activity. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Vitis vinifera | |
| Geographical availability | Albania, Austria, Bulgaria, Corse, Cyprus, Czechoslovakia, France, Germany, Greece, Hungary, Iran, Iraq, Italy, Kirgizstan, Krym, Lebanon-Syria, North Caucasus, Palestine, Romania, Sardegna, Sicilia, Switzerland, Tadzhikistan, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, Yugoslavia | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT, S6 kinase, S6 , VEGF, HIF-1alpha | |
| Gene or Protein evidence | Consistent with this result, GSE-suppressed phosphorylation of several important components involved in HIF-1alpha protein synthesis, such as Akt, S6 kinase and S6 protein. Furthermore, in the MDA-MB-231 tumor, we found that GSE treatment inhibited the expression of VEGF and HIF-1alpha and the phosphorylation of S6 kinase without altering the subcellular localization of HIF-1alpha, correlating with reduced vessel density and tumor size. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken together, this study indicates that GSE is a well-tolerated and inexpensive natural VEGF inhibitor and could potentially be useful in cancer prevention or treatment. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, U251, MDA-MB-468 | |
| Additional information | Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion. | |
| PubChem ID | NA | |
| Additional PMIDs | 23754570 31870115 19139005 10914742 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30478388-2 | |
| Safety | NA |