| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1707 | |
| Phytochemical name or plant extracts | Grape leaves extract | |
| PMID | 31918283 | |
| Literature evidence | In summary, our study provides novel insights regarding the activity of salidroside against gastric cancer and contributes to the clinical application of salidroside combined with autophagy inhibitors as a chemotherapeutic strategy for human gastric cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic and Aqueous extract | |
| Source of phytochemicals or plant Extracts | Vitis vinifera | |
| Geographical availability | Albania, Austria, Bulgaria, Corse, Cyprus, Czechoslovakia, France, Germany, Greece, Hungary, Iran, Iraq, Italy, Kirgizstan, Krym, Lebanon-Syria, North Caucasus, Palestine, Romania, Sardegna, Sicilia, Switzerland, Tadzhikistan, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, Yugoslavia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 | |
| Gene or Protein evidence | In addition, the expression of the pro-apoptotic gene Bax was increased and that of the anti-apoptotic gene Bcl-2 was decreased in a dose-dependent manner, when both MCF-7 and HepG2 cells were cultured with one of the two extracts for 72 h. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | HepG2 and MCF-7 cell proliferation decreased with increasing concentration of extracts (0.5, 1, and 2 mg/mL) added to the culture during a period of 1⁻72 h. | |
| Cell line/ mice model | HepG2, MCF-7 | |
| Additional information | Finally, our results suggested that ASE crude extract from grape leaves represents a source of bioactive compounds such as phenols, with potential antioxidants activity, disclosing a novel antiproliferative effect affecting only HepG2 and MCF-7 tumor cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30478388-2 | |
| Safety | NA |