| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-542 | |
| Phytochemical name or plant extracts | Gracillin (NSC-698787) | |
| PMID | 12820229 | |
| Literature evidence | By an analysis of COMPARE software, no compounds in the NCI's database had similar mean graphs to those of methyl protoneogracillin and gracillin, respectively, indicating potential novel mechanism(s) of action involved. | |
| IUPAC name | (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-2-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Saponin | |
| Source of phytochemicals or plant Extracts | Dioscorea collettii | |
| Geographical availability | China South-Central, China Southeast, Japan, Laos, Myanmar, Taiwan, Thailand, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Gracillin was cytotoxic against most cell lines with GI(50), TGI and LC(50) at micromolar levels, but no activity against EKVX (non-small cell lung cancer), HT29 (colon cancer), OVCAR-5 (ovarian cancer), and SN12C (renal cancer). | |
| Cell line/ mice model | CCRF-CEM, RPMT-8226, KM12, SF-539, U251, M14, 786-0, DU-145, MDA-MB-435 | |
| Additional information | Put all in together, methyl protoneogracillin has been selected as a potential anticancer candidate for hollow fi ber assay to nude mice, but gracillin will not be pursued due to lack of selectivity against human cancer diseases. | |
| PubChem ID | 159861 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:317817-1 | |
| Safety | NA |