| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-423 | |
| Phytochemical name or plant extracts | Goniothalamin | |
| PMID | 26987063 | |
| Literature evidence | The present study indicated that goniothalamin may be further used as a potential therapeutic candidate or may offer an alternative treatment for breast cancer. | |
| IUPAC name | (2R)-2-[(E)-2-phenylethenyl]-2,3-dihydropyran-6-one | |
| Phytochemicals’ class or type of plant extracts | Styrly-lactone | |
| Source of phytochemicals or plant Extracts | Cryptocarya latifolia | |
| Geographical availability | Cape Provinces, KwaZulu-Natal | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p38, JNK1/2, AKT, Bax, Bcl-2 | |
| Gene or Protein evidence | Therefore, goniothalamin promoted apoptosis associated with autophagy induction in SK-BR-3 cells through p-p38 and p-JNK1/2 upregulation and p-Akt downregulation. Goniothalamin also increased the Bax/Bcl-2 ratio and expression of cleaved caspase-7, cleaved caspase-9 and cleaved PARP, but decreased Bcl-2 expression. | |
| Target pathways | MAPK signaling | |
| IC50 | 10±0.45 μg/ml aginst SKBR-3 | |
| Potency | The present study indicated that goniothalamin may be further used as a potential therapeutic candidate or may offer an alternative treatment for breast cancer. | |
| Cell line/ mice model | SKBR-3 | |
| Additional information | In addition, goniothalamin induced apoptosis via p-JNK1/2 and p-p38 upregulation and inhibited cell survival via p-ERK1/2 and p-Akt downregulation. | |
| PubChem ID | 6440856 | |
| Additional PMIDs | 26987063 23244123 33463303 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:463966-1 | |
| Safety | NA |