| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-735 | |
| Phytochemical name or plant extracts | Gnetin H | |
| PMID | 12135100 | |
| Literature evidence | Six stilbenes showed cytotoxic activity in a dose-dependent manner, and especially did potent cytotoxic activity against C6 (mouse glioma) cancer cell with IC50 values ranging from 8.2 to 20.5 microg/ml. trans-Resveratrol showed significant cytotoxic activity against HepG2 (liver hepatoma) and HT-29 (colon) human cancer cell lines with IC50 values of 11.8 and 25.2 g/ml, respectively. | |
| IUPAC name | 5-[(2S,3S,5S,6S)-3-(3,5-dihydroxyphenyl)-2,6-bis(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3,5,6-tetrahydrofuro[3,2-f][1]benzofuran-5-yl]benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Stilbenoid | |
| Source of phytochemicals or plant Extracts | Paeonia lactiflora | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Chita, Inner Mongolia, Khabarovsk, Manchuria, Mongolia, Primorye | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 12.9 μg/ml against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, Hela, , HT-29, HePG2 | |
| Additional information | PAE and gnetin H suppressed the phosphorylation of Syk, protein kinase C (PKC)μ, phospholipase Cγ, and the mitogen-activated protein kinases, c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase. | |
| PubChem ID | 9852931 | |
| Additional PMIDs | 24832111 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:711802-1 | |
| Safety | NA |