| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-440 | |
| Phytochemical name or plant extracts | Glycyrrhizin | |
| PMID | 28506909 | |
| Literature evidence | Triple negative breast cancer(TNBC) has generated growing interests due to its aggressive biologic behavior and absence of targeted therapy approach. | |
| IUPAC name | (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid saponin | |
| Source of phytochemicals or plant Extracts | Glycyrrhiza glabra | |
| Geographical availability | Afghanistan, Albania, Bulgaria, Central European Rus, China North-Central, Cyprus, East Aegean Is., East European Russia, Greece, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Krym, Lebanon-Syria, Mongolia, North Caucasus, Pakistan, Palestine, Romania, Sardegna, Saudi Arabia, Sicilia, South European Russi, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan, Ukraine, Uzbekistan, West Siberia, Xinjiang, Yugoslavia | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | AKT pathway ERK and JNK of MAPK pathway | |
| IC50 | NA | |
| Potency | Collectively, our results demonstrate that GA, instead of GL, is a better candidate for TNBC treatment because of its anti-cancer effect and sensitization of topoisomerase IIα inhibitor. | |
| Cell line/ mice model | MDA-MB-231, HeLa, MCF-7 | |
| Additional information | However, GL showed protection and detoxication by decreasing reactive oxygen species generation, maintaining GSH and differentially modulating apoptosis, AKT pathway, ERK and JNK of MAPK pathway. | |
| PubChem ID | 14982 | |
| Additional PMIDs | 18849542 24696551 28506909 20857541 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496941-1 | |
| Safety | NA |