| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-493 | |
| Phytochemical name or plant extracts | Glycyrrhiza glabra extract | |
| PMID | 29150398 | |
| Literature evidence | The hydroalcoholic extract showed potent inhibition of CYP1B1 in both Sacchrosomes as well as in live cells with IC50 values of 21 and 16 µg/mL, respectively. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hydroalcoholic extract | |
| Source of phytochemicals or plant Extracts | Glycyrrhiza glabra | |
| Geographical availability | Libya | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | P450 1B1, CYP1B1, CYP1A1 | |
| Gene or Protein evidence | Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme With an objective to discover cisplatin-resistance reversal agents, herein, we report the evaluation of Glycyrrhiza glabra (licorice) extracts and its twelve chemical constituents for inhibition of CYP1B1 (and CYP1A1) enzyme in Sacchrosomes and live human cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The hydroalcoholic extract of G. glabra and quercetin (4) showed complete reversal of cisplatin resistance in CYP1B1 overexpressing triple negative MDA-MB-468 breast cancer cells. | |
| Cell line/ mice model | MDA-MB-468 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496941-1 | |
| Safety | NA |