| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-443 | |
| Phytochemical name or plant extracts | Glycybridin D (4) | |
| PMID | 28140583 | |
| Literature evidence | A number of compounds significantly activate Nrf2, inhibit tyrosinase or PTP1B, inhibit LPS-induced NO production and NF-κB transcription, and inhibit the proliferation of human cancer cells (HepG2, SW480, A549, MCF7). | |
| IUPAC name | 8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethyl-3-(3-methylbut-2-enyl)chromen-5-ol | |
| Phytochemicals’ class or type of plant extracts | Phenolic compound | |
| Source of phytochemicals or plant Extracts | Glycyrrhiza glabra | |
| Geographical availability | Afghanistan, Albania, Bulgaria, Central European Rus, China North-Central, Cyprus, East Aegean Is., East European Russia, Greece, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Krym, Lebanon-Syria, Mongolia, North Caucasus, Pakistan, Palestine, Romania, Sardegna, Saudi Arabia, Sicilia, South European Russi, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan, Ukraine, Uzbekistan, West Siberia, Xinjiang, Yugoslavia | |
| Plant parts | Root and Rhizome | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer, Colon cancer | |
| Target gene or protein | PTP1B | |
| Gene or Protein evidence | The two new compounds 4 and 8 and the six known compounds 16, 35, 37, 39, 47, and 52, all bearing an isoprenyl and an ortho-hydroxy group, dose-dependently inhibited PTP1B with IC50 values ranging from 5.0 to 7.9 μM. | |
| Target pathways | NA | |
| IC50 | 4.6 to 6.6 μM | |
| Potency | Glycybridin D (4) showed moderate cytotoxic activities against the four cancer cell lines, with IC50 values ranging from 4.6 to 6.6 μM. 90.7 ± 1.0 % cytotoxic activity against MCF-7 | |
| Cell line/ mice model | HepG2, SW480, A549, MCF-7 | |
| Additional information | Further studies indicated that 4 (10 mg/kg, ip) decreased tumor mass by 39.7% on an A549 human lung carcinoma xenograft mice model, but showed little toxicity. | |
| PubChem ID | 132504088 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496941-1 | |
| Safety | NA |