| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-446 | |
| Phytochemical name or plant extracts | Glycybridin C (3) | |
| PMID | 28140583 | |
| Literature evidence | A number of compounds significantly activate Nrf2, inhibit tyrosinase or PTP1B, inhibit LPS-induced NO production and NF-κB transcription, and inhibit the proliferation of human cancer cells (HepG2, SW480, A549, MCF7). | |
| IUPAC name | (2R)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-2-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]propan-1-one | |
| Phytochemicals’ class or type of plant extracts | Phenolic compound | |
| Source of phytochemicals or plant Extracts | Glycyrrhiza glabra | |
| Geographical availability | Afghanistan, Albania, Bulgaria, Central European Rus, China North-Central, Cyprus, East Aegean Is., East European Russia, Greece, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Krym, Lebanon-Syria, Mongolia, North Caucasus, Pakistan, Palestine, Romania, Sardegna, Saudi Arabia, Sicilia, South European Russi, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan, Ukraine, Uzbekistan, West Siberia, Xinjiang, Yugoslavia | |
| Plant parts | Root and Rhizome | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | For instance, 3 showed cytotoxicities against HepG2, MCF7, and SW480 cell lines (75.2%, 82.1%, and 72.0% growth inhibition, respectively) but no significant effect on A549 cells (7.5%). | |
| Cell line/ mice model | HepG2, SW480, A549, MCF-7 | |
| Additional information | NA | |
| PubChem ID | 132504087 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496941-1 | |
| Safety | NA |