| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1118 | |
| Phytochemical name or plant extracts | Glehnia littoralis extract | |
| PMID | 26745047 | |
| Literature evidence | In summary, the current study showed that GL could serve as a potential source of chemotherapeutic or chemopreventative agents against human breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Glehnia littoralis | |
| Geographical availability | Alaska, British Columbia, California, China North-Central, China Southeast, Japan, Khabarovsk, Korea, Kuril Is., Manchuria, Nansei-shoto, Oregon, Primorye, Sakhalin, Taiwan, Vietnam, Washington | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | CDK4, Cyclin D1 , p21, p27 | |
| Gene or Protein evidence | Our reuslts indicated that GL root extract arrested the proliferation of MCF-7 cells in G1 phase through inhibition of CDK4 and cyclin D1 via increased induction of p21 and p27. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In summary, the current study showed that GL could serve as a potential source of chemotherapeutic or chemopreventative agents against human breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | G. littoralis extract promots cell proliferation, neuroblast differentiation, and neuronal maturation in the hippocampal DG, and neurogenic effects might be closely related to increases of BDNF and TrkB proteins by G. littoralis extract treatment. | |
| PubChem ID | NA | |
| Additional PMIDs | 29521292 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:842779-1 | |
| Safety | NA |