| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-438 | |
| Phytochemical name or plant extracts | Gleditsia sinensis extract | |
| PMID | 12673105 | |
| Literature evidence | Antiproliferative activity of the extract of Gleditsia sinensis fruit on human solid tumour cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Gleditsia sinensis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Manchuria | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Liver cancer, Oesophageal squamous cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The mean MTT(50) (the mean concentration of GSE to reduce MTT activity by 50%) ranged from 16 to 20 microg/ml of GSE. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HepG2 , SLMT-1 | |
| Additional information | An anchorage-independent clonogenicity assay showed that all of the four solid tumour cell lines gradually lost their regeneration potential after treatment with GSE, DNA fragmentation and TUNEL analysis demonstrated that the action of GSE is both dose- and time course-dependent. | |
| PubChem ID | NA | |
| Additional PMIDs | 12673105 12851730 14654990 15138634 16211265 16273300 29473437 26559244 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496614-1 | |
| Safety | NA |