| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1117 | |
| Phytochemical name or plant extracts | Glaucium flavum extract | |
| PMID | 23860409 | |
| Literature evidence | G. flavum root crude alkaloid extract inhibited breast cancer cell proliferation and induced G2/M phase cycle arrest and apoptosis without affecting normal cells, which is a highly awaited feature of potential anti-cancer agents. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Dichloromethane extract | |
| Source of phytochemicals or plant Extracts | Glaucium flavum | |
| Geographical availability | Albania, Algeria, Baleares, Belgium, Bulgaria, Canary Is., Corse, Denmark, East Aegean Is., France, Germany, Great Britain, Greece, Iran, Ireland, Italy, Kriti, Krym, Lebanon-Syria, Libya, Morocco, Netherlands, North Caucasus, Norway, Palestine, Poland, Romania, Sardegna, Sicilia, Sinai, Spain, Sweden, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Yugoslavia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | We report for the first time that G. flavum extract may represent a new promising agent for cancer chemotherapy. | |
| Cell line/ mice model | MDA-MB-435, MDA-MB-231, Hs578T | |
| Additional information | The chromatographic profile of the dichloromethane extract of G. flavum root showed the presence of different constituents including the isoquinoline alkaloid protopine, as the major compound. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:673167-1 | |
| Safety | NA |