| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2109 | |
| Phytochemical name or plant extracts | Ginsenoside Rp1 | |
| PMID | 21748437 | |
| Literature evidence | One such natural agent is ginseng (Panax ginseng), which is traditionally used in some parts of the world as a popular remedy for various diseases including cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Component of ginseng | |
| Source of phytochemicals or plant Extracts | Panax ginseng | |
| Geographical availability | Khabarovsk, Korea, Manchuria, Primorye | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | IGF-1R | |
| Gene or Protein evidence | Our findings further indicated that Rp1 decreased the stability of the IGF-1R protein in breast cancer cells. | |
| Target pathways | IGF-1R/Akt pathway | |
| IC50 | NA | |
| Potency | Therefore, we suggest that Rp1 has potential as an anticancer drug and that IGF-1R is an important target for treatment and prevention of breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, T-47D | |
| Additional information | We first tested the efficacy of Rp1 against human breast cancer cell lines. Treatment with Rp1 inhibited breast cancer cell proliferation and inhibited both anchorage-dependent and -independent breast cancer cell colony formation. In addition, treatment with 20 μM Rp1 induced cycle arrest and apoptosis-mediated cell growth suppression. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:91472-1 | |
| Safety | NA |